Hyperuricemia (HUA) is associated with endothelial dysfunction, vascular smooth muscle proliferation, and interstitial inflammatory infiltration through a variety of mechanisms, such as inducing intracellular oxidative stress, mitochondrial dysfunction, inflammatory response and activation of the renin-angiotensin system (RAS). 

Hyperuricemia is the most powerful predictor of gouty arthritis.

The two most common complaints associated with Hyperuricemia, are gouty arthritis and uric acid nephrolithiasis.

Causes

Primary Hyperuricemia

• Increased production of uric acid from urine
• Inefficient excretion of uric acid from the blood, resulting in high levels

Secondary Hyperuricemia

• Kidney disease – inefficient excretion in ratio to its production, thus causing Hyperuricemia.
• Certain medications - can cause increased levels of uric acid in the blood
• Endocrine or metabolic conditions - diabetes, or acidosis can cause Hyperuricemia
• Elevated uric acid levels may produce kidney problems or none at all.
• People may live for many years with elevated uric acid levels, and they do not develop gout or gouty arthritis.

HERBAL AND SAFER TREATMENT OPTION AVAILABLE

Ashwagandha (Withania somnifera) shows a significant decrease in beta-glucuronidase and lactate dehydrogenase levels in monosodium urate crystal-induced in experimental subjects.

Suranjan (Colchicum leuteum) exerts anti-inflammatory action by suppressing TNF-α, IL-6 and IL-1 beta levels which is one of the first requirements of patients of arthritis. Colchicine is also used in acute cases of GOUT.

Tagar (Valeriana wallichii) is rich in terpenes and sesquiterpenes which inhibit COX which is also the action of NSAIDs another mechanism of analgesia exhibited by TAGAR is by the K-ATP channel activation. The peripheral analgesic action is found out to be comparable to Aspirin.

Guduchi (Tinospora cordifolia) is proven to have anti-inflammatory and anti-arthritic action. Tinosporin is a natural diuretic agent which aids in the excretion of Serum Uric Acid. Tinosporin also possesses gastro protective activity which is a beneficial property while using it as an analgesic.

Punernava (Boerhavvia diffusa) has anti-inflammatory action and thus suppresses the symptoms of Gout. It also has a diuretic effect thus decreasing the amount of Uric Acid in blood.

Haritaki (Terminalia chebula) is having a wide spectrum of pharmacological and medicinal activities like anti-inflammatory, anti-arthritic, antioxidant and free radical scavenging, hepatoprotective, gastrointestinal motility improving and antiulcerogenic, antispasmodic and immunomodulatory actions.

Aimil takes the pride to manage or treat tough diseases through its scientifically proven and clinically verified result-oriented formulations, standing at the top choice of physician for long term benefits to the health of their patients.

Neeri KFT provides primary kidney care with vital phyto-constituents acting synergistically as a natural nephroprotective. Neeri KFT provides a high strength of antioxidant protection to the kidneys. Punernava (Boerhavvia diffusa), Guduchi (Tinospora cordifolia) and many more herbs in Neeri KFT work to relieve asymptomatic hyperuricemia.

Muscalt forte available in syrup/ tablet and spray to help arthritic conditions having above mentioned and many more herbs to provide safer options for Geriatric patient’s arthritic pains along with taking care of gastric health.

Foods that are high in purine should be avoided:

• All organ meats, meat extracts, and gravy
• Yeasts, and yeast extracts (such as beer, and alcoholic beverages)
• Spinach, beans, peas, lentils, oatmeal, cauliflower and mushrooms

Foods that are low in purine may be taken:

• Refined cereals - bread, flour, cakes
• Milk and milk products, eggs
• Lettuce, tomatoes
• Cream soup without meat stock
• Water, fruit juice, carbonated drinks
• Peanut butter, fruits, and nuts

The bottom line

Having asymptomatic hyperuricemia, diet and lifestyle changes can help lower uric acid levels in your blood.

If uric acid levels aren’t controlled, may be at risk for developing:

• Gouty arthritis
• Chronic gout
• Kidney problems
• Hypertension
• Diabetes

Recommendations

• Keep well hydrated, drinking 2 to 3 litres of water per day
• Avoid caffeine and alcohol, as these can contribute to problems with uric acid and hyperuricemia.