Author: Aimil

Urinary stones affect 10–12% of the population in industrialized countries. There are only a few geographical areas in which stone disease is rare, e.g., in Greenland and in the coastal areas of Japan. The incidence of urinary stones has been increasing over the last years while the age of onset is decreasing. With a prevalence of > 10% and an expected recurrence rate of ~ 50%, the stone disease has an important effect on the healthcare system. Once recurrent, the subsequent relapse risk is raised and the interval between recurrences is shortened. Features associated with recurrence include a young age of onset, positive family history, infection stones and underlying medical conditions. Epidemiological studies revealed that nephrolithiasis is more common in men (12%) than in women (6%) and is more prevalent between the ages of 20 to 40 in both sexes. The etiology of this disorder is multifactorial and is strongly related to dietary lifestyle habits or practices. Increased rates of hypertension and obesity, which are linked to nephrolithiasis, also contribute to an increase in stone formation.

Management of stone disease depends on the size and location of the stones. Stones larger than 5 mm or stones that fail to pass through, usually treated by some interventional procedures such as extracorporeal shock wave lithotripsy (ESWL), ureteroscopy (URS), or percutaneous nephrolithotomy (PNL). Unfortunately, the propensity for stone recurrence is not altered by removal of stones with ESWL and stone recurrence is still about 50%. In addition, ESWL might show some significant side effects such as renal damage, ESWL induced hypertension or renal impairment.

Although there are a few recent reports of beneficial effects of medical treatments in enhancing clearance of stones in the distal ureters, there is still no satisfactory drug to use in clinical therapy, especially for the prevention or the recurrence of stones. In this regard, many plants have been traditionally used to treat kidney stones and have been shown to be effective.

Citrate is a known inhibitor of calcium-based stones. Its presence in urine decreases the saturation of calcium oxalate and calcium phosphate by forming soluble complexes with calcium. By its conversion through bicarbonate citrate increases urinary pH which induces an additional citraturic response by slowing renal citrate metabolism and impairing citrate reabsorption. However, pharmacological potassium citrate supplementation requires a rigorous schedule of numerous tablets or liquid supplements taken routinely 3 to 4 times a day. Patient compliance significantly decreases when medications are administered more than once daily. Patients therefore could benefit from intake of dietary citrate. Citrus fruits and juices are a known natural source of dietary citrate. Several studies investigated the influence of orange and grapefruit juice on urinary variables and the risk of crystallization.

In comparison to orange and grapefruit juice, lemon juice [Citrus limon (L.) Burm. f.] contains the highest concentration of citrate, nearly 5 times that of oranges. So far many studies have investigated lemonade therapy as a potential treatment for hypocitraturic nephrolithiasis. The studies concluded that consumption of lemonade significantly increased urinary citrate excretion and therefore could be a useful adjunctive therapy in patients with hypocitraturia. Four ounces of lemon juice provide 5.9 g citric acid. When diluted in 32 oz (960 mL) of water, lemonade could not only promote dietary citrate but also fluids.

Cranberry (Vaccinium macrocarpon Ait.) juice is another juice that has been investigated in clinical trials for its ability to influence urinary biochemical and physicochemical risk factors associated with CaOx kidney stones. Since compounds in cranberry juice have been shown to inhibit the attachment of bacteria to the epithelial lining of the urinary tract, the same compounds could inhibit the attachment of CaOx crystals and stone-promoting bacteria to renal epithelial cells.

A unique herbomineral formulation of Aimil Pharmaceuticals, brand name NEERI, enriched with potent anti-calcifying herbs, rich source of citrates, other micronutrients and supplements stone inhibitors which prevents calcium from binding with oxalate or Phosphates. Neeri significantly increases excretion of stone inhibitor molecules which forms soluble complex with calcium which ultimately decreases the concentration of urinary calcium, this action inhibits the formation of kidney stones. Neeri inhibits calculogenesis by regularising the mineral balance and balancing the crystalloid-colloid imbalance. It prevents the accumulation, deposition and super-saturation of calculogenic chemicals like oxalic acid and calcium hydroxyproline in urine.

 Kidneys are our bodies' unsung heroes and are vital in helping us maintain our health and vitality perform the most of major excretory processes in the human body, hence become the prime target organ for various circulating toxins that may cause nephrotoxicity. Kidneys filter about 180L of blood per day and work 24/7 keeping all other body systems in balance.

Neeri-KFT, a  polyhedral sugar free syrup manufactured by Aimil Pharmaceuticals India Ltd., is especially designed for restoring biochemical parameters and correcting the impaired renal physiology. It is mainly prescribed for improving the poor kidney functions that may be due to many conditions like diabetes, glomerulonephritis, hypertension, generalized oedema, nephrotoxicity etc.

The Phytoconstituents available in the herbs that are used in this formulation dominantly act as potent anti-oxidant, immune modulator and nephroprotective by multi mechanism. Thereby tends check further degenerative alterations and promotes restoring the functional capacity of nephrons, and normalizes the deviated functional parameters of kidney like serum creatinine, serum urea, serum proteins etc. The NEERI-KFT contains extracts of the following herbs.

Punernava (Boerhavia diffusa L.): due to its use in the treatment of diseases of urinary system and the possibility of the presence of regenerative property of Punernava as its name suggests and due to the excellent regenerative capacity possessed by the kidneys. Punernava has diuretic, anti-inflammatory, anti-oxidant and possible antibacterial and cardiotonic effect. By virtue of such properties this drug initiates early recovery of the kidneys from different diseases and facilitates regenerative repair.

Giloe (Tinospora cordifolia (willd.) Miers): Giloe is a potent plant material that is widely used in the Indian system of medicines as a tonic, vitaliser, immunomodulator and as a remedy for metabolic disorders. The plant stem has been considered as an indigenous source of medicine with anti-diabetic, immunomodulatory, hepatoprotective, and anti-pyretic actions. A variety of active components derived from the plant like alkaloids, steroids, diterpenoid that are responsible for various activities like anti-diabetic, anti-periodic, anti-spasmodic, anti-inflammatory, anti-arthritic, anti-oxidant, anti-allergic, anti-stress, anti-leprotic, anti-malarial, hepatoprotective, immunomodulatory and anti-neoplastic activities.

Kamal (Nelumbo nucifera Gaertn.): There are several therapeutic benefits of this plant for which different parts are used. Several bioactive compounds have been derived from different parts of the plant belonging to different chemical groups, including alkaloids, flavonoids, glycosides, triterpenoid, vitamins etc. Pharmacological activities of different extracts of rhizomes and flowers, and the compounds isolated from these have been demonstrated activities like antioxidant, anti-inflammatory, anti-diabetic, hypoglycaemic, immunomodulatory and other activities.

Palashpushp (Butea monosperma (Lam.) Taub.): Butea monosperma is reported to have medicinal potential in various ancient literatures. The plant is known for antioxidant, anti-obesity, anticancer, and chemoprotective potential and also known for hepatoprotective and antidiabetic properties. The two principal phytochemicals, Isobutrin and butrin, are responsible for hepatoprotective and antioxidant activity. By the virtue of antioxidant activity, Butea monosperma demonstrated nephroprotective activity.

Gokshru (Tribulus terrestris L.): Gokshru is one of Ayurveda’s best herbs for the kidneys. The herb is very effective in most of the urinary tract disorders. This is because it promotes the flow of urine, and cool and sooth the membranes of the urinary tract. The herb has also been used to remove urinary stones and stop bleeding. It is known to nourish and to strengthen the kidneys and reproductive organs. Recent pharmacological studies demonstrated that Gokshru significantly reduced the excretion of oxalate, calcium, and phosphate along with decreased levels of blood urea nitrogen, uric acid and creatinine in serum and also reduced hyperoxaluria that caused oxidative stress and restored antioxidant enzyme activity and their expression profile in kidney tissue.

Sigru (Moringa oleifera Lam.): Sigru is popularly called ‘the miracle tree’ with potentials for the treatment of various diseases such as cancer, hypertension and diabetes mellitus. It has been reported that leaves contain abundant glucosinolates, isothiocyanates, carotenoids, vitamins, high proteins and carbohydrates. Leaves are reported to have 4 times the vitamin A of carrots, 7 times the vitamin C of oranges, 4 times the calcium of milk, 3 times the potassium of bananas, 3⁄4 the iron of spinach, and 2 times the protein of yogurt”. People may be less likely to develop stones in the kidneys, bladder or uterus if they ingest moringa extract. Moringa contains high levels of antioxidants that might aid toxicity levels in the kidneys.

khas (Chrysopogon zizanioides (L.) Roberty; Veteveria zizanioides (L.) Nash.): Root of Vetiveria zizanioides have been suggested in the Indian system of medicine for a number of diseases. The essential oil of vetiver root has been shown to possess antioxidant activity. The health benefits of Vetiver Essential Oil can be attributed to its properties like anti-inflammatory, anti-septic, aphrodisiac, cicatrisant, nervine, sedative, tonic and vulnerary. The roots possess antifungal, cooling, diaphoretic, aromatic, expectorant, stimulant properties which help to treat skin ailments, insomnia, hysteria, amentia, asthma, amenorrhoea, gall stones and kidney problems and it stimulates urine production and breaks stone.

Varun (Crateva nurvala Buch.-Ham.): The bark of Varun is believed to have many properties such as antioxidant, antimicrobial, and urinary-renal, contraceptive and anti-inflammatory supportive qualities. It is recommended by the Ayurveda in the treatment of various urinary problems including stones in kidney, ureters and bladder. The key constituents of crataeva nurvala are alkaloids; triterpenes; tannins; saponins; flavonoids; plant sterols; and glucosilinates which exhibited diuretic, antilithiatic, and anti-inflammatory activities. Scientific research has indicated that a constituent of varuna, lupeol, deactivates the enzyme glycolate oxidase, reducing the body’s production of oxalates which combine with calcium to form kidney stones. Therefore, varuna is an important Ayurvedic herb that is especially valued for its effectiveness in the treatment of renal conditions and to treat infections of the urinary tract.

Chaulai (Amaranthus spinosus L.): Chaulai is known for its several pharmacological properties. It is used as anti-inflammatory, anti-malarial, antibacterial, anti-diuretic, antiviral and hepatic disorders. Scientific studies on A. spinosus have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antinephritic, antidiabetic, antitumor, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepato-protective, spermatogenic, antifertility, antimalarial, antioxidant properties, etc. The active Phyto constituents presence in the plant are alkaloids, flavonoids, glycosides, phenolic acids, steroids, amino acids, terpenoids, lipids, saponin, betalain, b-sitosterol, stigmasterol, linoleic acid, rutin, catechuic tannins and carotenoids.

Kasni (Cichorium intybus L.):  Most parts of the plant contain a potpourri of nutrients ranging within carbohydrates, proteins, vitamins, minerals, soluble fiber, trace elements, and bioactive phenolic compounds, which are responsible for the various nutritive, prophylactic, and therapeutic qualities of chicory. Inulin, coumarins, tannins, monomeric flavonoids, and sesquiterpene lactones are some of the major phytocompounds mostly found in chicory plants. Kasni is widely used medicinally to treat various ailments as a diuretic, nephroprotective and tonic to kidneys and as an Antioxidant to diabetes. The inulin, Caffeic acid and chlorogenic acid have been described as potential antidiabetic agents. These compounds were also able to stimulate insulin secretion from an insulin-secreting cell line and islets of Langerhans. Recent study showed that aqueous extract of Kasni was able to repair the kidney damage.

Makoya (Solanum nigrum L.): Traditionally makoya is frequently used to treat human health problems. The scientific investigation from many research findings shows that makoya has various bioactive ingredients such as alkaloids, solanins, saponins, flavonoids, tannins, steroidal glycoalkaloids, steroidal genin and vitamins. These constituents are responsible for diverse activities including: anti-inflammatory, antibacterial, anti-diabetic, anti-fungal, anti-oxidant, hepatoprotective, nephroprotective and cytoprotective effects. In addition, these bioactive constituents have free radical scavenging capacity and anti-lipid peroxidation activities by stabilization of plasma membranes as well as repair of liver and kidney tissue damage. Moreover, whole plant extract have the capacity to reverse kidney damages to near normal levels if pathological change occurs.

Shirish (Albizia lebbeck (L.) Benth.): Shirish contains alkaloids, tannins, saponins and flavonoids which has medicinal action. Some of the most impressive health benefits of Siris include its ability to relieve stress and anxiety, improve symptoms of depression, stimulate the circulatory system, reduce signs of aging, prevent certain chronic illnesses, help digestive issues, lower cholesterol, prevent respiratory distress, and eliminate inflammation in various parts of the body. It is also used in frequent urination, painful urination, and urinary tract infections. Recent study indicates the considerable antihyperglycemic, antihyperlipidemic, antioxidant & pancreas/renal/hepatic/cardiac protective action.

Lal chandan (Pterocarpus santalinus L.): In the traditional system of medicine, the decoction from the heartwood of Lal Chandan is attributed various medicinal properties. Methanol and aqueous extracts of heartwood of lal chandan have shown anti-diabetic, anti-inflammatory and anti-hepatotoxicity activities and act by improving insulin secretion and alterations in the carbohydrate and lipid metabolism. The phytochemicals responsible for these activities are reported to be alkaloids, flavonoids, and triterpenoids, presence in the heart wood of Lal Chandan. Scientific study showed that the flavonoid and tannoid compounds present in the heart wood of Lal Chandan might have protective activity against alcohol-induced oxidative/nitrosative stress mediated kidney damage.

Haridra (Curcuma longa L.): Haridra has been used in India for thousands of years as a spice and medicinal herb. Haridra has positive consequences in terms of cardiovascular and nephroprotection because of its antibacterial, antiviral, anti-inflammatory and anti-oxidative effects. Curcumin, the main bioactive compound isolated from Haridra, is a nutritional ingredient with negligible side effect. It modulate enzymes, cytokines, transcription factors, growth factors, receptors, micro RNA (miRNA), signaling molecules and reactive oxygen species and thereby positively affect inflammation, oxidative stress and as antidiabetics and renal protective.

Anantmool (Hemidesmus indicus L.): Anantmool has been used by the native healers in India for nephritic complaints, syphilis, and sore mouth. Today, anantamul is receiving renewed attention that may have health benefits for blood purification, kidney and urinary disorders, and skin infections. Anantmool helpes in the management of renal impairment, which was induced by gentamicin in rats. Anantamul has been indicated for all types of ulcers, skin diseases, urticaria, fever, diabetes, loss of appetite, bronchial asthma/respiratory tract disorders, vomiting,  cough, thirst, menorrhagia), atisara (diarrhea and toxicity/poisons. Recent scientific studies showed that the extract of the root  had ameliorative effects on liver, kidney, and pancreatic injury. Anantamul’s protective effects have been linked to its chemical constituents, namely saponins, tannins, phenols, terpenoids, flavonoids, and coumarins. Anantmool has also demonstrated anti-inflammatory, Antioxidant, Cardioprotective, Diuretic, Hepatoprotective Nervous Disorders, Renoprotective activity in laboratory studies.

Dhania (Coriandrum sativum L.): Dhania is an important medicinal plant known for its hepatoprotective, diuretic, carminative, digestive and antihelminthic potentials. Scientific study demonstrates that Dhania fruit is a potential source of nephroprotective activity, with flavonoids and polyphenols as the major components. The methanolic extract of Coriander seeds possess remarkable anti-oxidative behaviour and exhibit a synergistic effect against hepato-renal toxicity. Coriander is good for diabetes patients and it can stimulate the insulin secretion and lower the blood sugar levels.

Revand chini (Rheum emodii L.): Revand Chini has been used in various traditional systems as laxative, tonic, diuretic and to treat fever, cough, indigestion, menstrual disorder since antiquity. Revand chini has been described having diuretic liver stimulant, purgative/cathertic, stomachic properties and its usefulness in kidney disorders. The most common constituents of Rheum emodi are anthraquinone (rhein, chrysophanol, aloe-emodin, emodin, physcion, and their glycosides) and stilbene (picetannol, resveratrol and their glycosides). Studies have shown that Rheum emodi possess anticancer, antioxidant, anti-inflammatory, antimicrobial, antifungal, antidyslipidemic, antiplatelet, antidiabetic, antiulcer, hepatoprotective, immunoenhancing and nephroprotective activities. Recent scientific investigations provide evidences that Water Soluble fraction of Revand chini has nephroprotective effect on all the proximal tubule segments possibly through antioxidant action of the tannins present in the fraction. Water insoluble fraction also improved the renal function by protecting S2 segment of proximal tubule nephrotoxicity induced by metals viz cadmium chloride and mercuric chloride in rat models.

Kakri Beej (Cucumis utilissimus Roxb.): The Kakri seed is having diuretic, lithotriptic, laxative, antioxidant, demulcent and cooling properties. They are used as digestive, febrifuge, antitussive, demulcent, and vermifuge. Their extract is  used as an anti-diabetic and is useful in chronic eczema, in renal disorders such as kidney and bladder stones, ulcers in the urinary tract and stomach, painful and burning micturation, jaundice, vitiligo, ascites, suppression of urine, chronic fevers, inflammation of the liver and kidney, and in general debility in the Indian traditional medicine. Scientific study showed that chloroform extracts of Kakri seed treated hyperoxaluria, calcium, and uric acid, and renal function was improved. Furthermore, high serum levels of urea nitrogen, creatinine and uric acid were significantly reduced by the extract.

Papita (Carica papaya L.): The unripe Papita fruit is used traditionally among the for the treatment of various human and veterinary diseases including malaria, hypertension, diabetes mellitus, hypercholesterolaemia, jaundice, intestinal helminthiasis and for the management of sickle cell anaemia and treatment of poison related renal and hepatic disorders. Papita contains a substantial amount of potassium, which is very helpful in cleaning or washing out the toxic depositions in the kidneys. The fruit also helps in reducing the concentration of uric acid in the blood and reducing the chances of kidney damage and the formation of renal calculi in that organ. Scientific study showed that Papita has nephroprotective effect on CCl4 renal injured rats. Papita seeds are used to heal the damage to the kidney during the filtering process. It easily eradicates the toxins produced during the metabolism in the whole body and excretes toxins out through urine. Carpaine is an alkaloid present in the papaya seeds which detoxifies the toxins by making a chelate which is easily excreted out.

"A great fruit choice for the kidney diet"

Pineapple can be used as supplementary Nutritional fruit for good personal health. Pineapple fruits are an excellent source of Vitamins and minerals.

Benefits of Pineapple

•  Detoxifier              •  Aids Digestion

•  Heart health         •  Kidney health

Detoxifier:

The enzyme bromelain in pineapple acts as a potent cleanser that balances the pH levels in the blood and relieving oedema through reduction of excess water in the body.

Digestion:

The sour unripe fruit improves digestion, increase appetite and relieves dyspepsia. Kidney patients constantly suffer from constipation and stomach issues. Pineapples, because of their fibre and water content, help to prevent constipation and promote regularity and a healthy digestive tract.

Healing and Inflammation:

Studies have shown that bromelain, an enzyme found in pineapples, can reduce swelling, bruising, healing time, and pain associated with injury and post-surgery wounds.

Blood pressure:

A common complication among Chronic Kidney Disease patients, the moderate potassium consumed from pineapple helps to lower blood pressure levels.

Heart Health:

As most kidney disease patients face heart complications, the leading cause of death in the Chronic Kidney Disease. The fibre, potassium, and vitamin C content in pineapple all support improved Heart Health.

In traditional system of medicine, Pineapple act as uterine tonic.

Do keep in mind:

•  Consuming pineapple during pregnancy may in some cases lead to miscarriages.

•  Ripe pineapple fruit in fact contain high levels of sugar, so it is not recommended for diabetics.

•  Pineapple fruit may, like any other fruit or nut cause allergic reactions in some people including red itchy skin, swollen lips and mouth. To avoid this, dip pineapple in salt water before consumption.

New Delhi, Jan 25 (PTI) Madhya Pradesh-based Jiwaji University and Delhi-based AIMIL Pharmaceutical firm have inked an MoU to develop new Ayurveda drugs using nanotechnology.

The pact is also aimed at standardising and scientifically validating the existing drug formulations in the ayurveda sector.

Former health secretary and ex-Director General of Indian Council of Medical Research, Dr. V M Katoch, who was present at the MoU signing function, lauded the improved co-ordination between research institutes and ayurvedic industry.

The MoU was signed between Jiwaji University Vice-Chancellor, Dr. Sangeeta Shukla and AIMIL Pharmaceutical Executive Director Sanchit Sharma.

"Ayurveda is the key to treating some of the incurable diseases. If old formulations are subjected to modern research, we will surely be able to develop world-class medicines with negligible side effects," Dr Katoch said.

Commenting on the development, AIMIL Pharmaceuticals (I) Ltd Executive Director Sanchit Sharma said, "AIMIL will pump in resources, like equipment and technology inputs, to help the University utilise its pool of qualified researchers to its optimal potential."

"It is a win-win situation for us. The arrangement will open new avenues for our faculty and students while giving AIMIL access to latest research feedback," said Vice Chancellor of Jiwaji University Sangita Shukla, while thanking the Union AYUSH Ministry for promoting research in ayurveda.
Highlighting the gains from tie-ups between researchers and industry, Dr. Katoch cited the example of DRDO-developed formulation Lukoskin to treat white spots or vitiligo while country's premier research agency, CSIR has developed anti-diabetes herbal drug formulation BGR-34.

The Union government has tied-up with AIMIL for marketing these two drugs which have made huge impact in lives of suffering masses throughout the country.

The Council of Scientific and Industrial Research (CSIR) has developed BGR-34, after standardisation and pre-clinical studies conducted jointly by its two labs – Central Institute of Medicinal and Aromatic Plants (CIMAP) and National Botanical Research Institute (NBRI).

It is meant to be used by newly diagnosed diabetes patients for management of the disease. Launched two years ago, BGR-34 is an add-on or adjuvant to existing diabetes treatment helping to maintain normal blood glucose levels, in addition to improving the immune system, releasing antioxidants and checking free radicals. PTI PLB RCJ

 

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But together we can win it next time

FIFATROL – A natural antibiotic

Combining benefits of both Ayurveda & Nature – A natural Multi drug combination to fight infections

 

 Testosterone is the most potent male hormone belonging to class of ‘Androgens’ which in Greek is a word for ‘man maker’ and indeed as the name suggests, testosterone is involved in almost all process of masculine development.
Testosterone is produced under the influence of GnRH (growth hormone releasing hormone) and is responsible for maintenance of all parameters of vigour, vitality and strength in males. Normal testosterone level leads to correct muscle strength and mass, optimum bone density, normal RBC production and optimum sperm production whereas low testosterone lowers the muscle bulk and strength, decreases energy output. Reduced testosterone lowers motivation and confidence and also inhibits new muscle growth and accelerates the building of body fat in the body.

Testosterone: the elixir of male system
Higher level of testosterone is necessary to reach the state of complete masculinity and to get optimum vigour, vitality and strength. Increasing the testosterone increases the sense of well-being, increases the sexual desire and performance. Optimal level of testosterone strengthens the muscles specially that of heart. It also increases RBC production which elevates the supply of oxygen and in turn leads to high energy in the body.

Naturally boosting testosterone
Increasing the testosterone is the most significant step to correct its deficiency & Ayurveda is one of the schools of thought which makes an amalgam of modern science and ancient wisdom, the concept of Ayurveda which aims to strike the right balance offers a treasure of herbs to elevate the levels of testosterone. Naturally increasing testosterone always balances the production of testosterone without over stimulating the production. Natural way of increasing testosterone also saves the person from the ill effects of synthetic testosterone therapy like enlargement of breast, sleep apnoea, limitation of sperm production and increased risk of deep vein thrombosis. Herbs like Ashwagandha (Withania somnifera), Gokhru (Tribulus terrestris), Kaunch (Mucuna pruriens) increases testosterone production and increases the efficacy of testosterone by sensitizing the testosterone receptors. Surajmukhi Beej (Helianthus annuus) and Akarkara (Anacyclus pyrethrum) supplements essential nutrients to optimise the function of leydig cells which produce testosterone. Shilajit (Black Bitumen) has a significant role in regulation of glucose metabolism which increases the energy production in the body. Safed musli (Asparagus adscendens) and Lata kumara satv (Abelmoschus moschatus) increases the endurance which is needed for boosting the strength of the body.

The essence of all these herbs has been tapped in Aimil’s Semento which increases vigour, vitality and strength. Semento, a blend of 26 Herbs helps in development of muscle mass and strength and also improve the sperm count and semen parameters.

Testosterone, with its role in male body, truly stands out as an important physiological hormone. In cases of deficiency, natural ways of boosting testosterone should be adopted which deliver the required action and are devoid of any side effects.

CAPTURING THE KEY TO BALANCE WOMEN HEALTH

Women are indispensable part of the society and their health is of high importance for multiple reasons. Women’s health does not refer only to her physical condition but to her total well-being. It is not determined solely by biological factors but also by effects of workload, nutrition and stress. Women’s emotional, social & physical well-being is an urgent priority since ages. But in the chaos of a woman’s daily life, healthy living may take back seat to chores, work, busy schedules, and more & that negated health of women leads to higher risks which are associated with their reproductive health. The female body always has an ongoing, complex interplay of hormones, and many things are responsible to upset this balance.  

 MANAGEMENT WITH AYURVEDA

As life goes on, women experience unique health issues & conditions such as Irregular menstruation, Dysmenorrhea, Pre-menstrual syndrome(PMS), Pre & Post-menopausal syndrome, Infertility and many more during their life cycle from menarche to menopause. Sometimes these conditions become threat to their reproductive health. Though allopathic medicines are available for all these problems but popping too many painkillers or increased dependency on synthetic hormones is not beneficial.

 The healing wisdom of Ayurveda offers an exclusive key for women to stay in balance because Ayurveda not only control but also prevent these common problems that women face. Ayurveda is a health care system to balance their body rhythms which are closely linked to nature. According to Ayurveda healthy menstrual cycles, fertility, menopause depends on a delicate balance by – 

• The subtle connection of gynaecological clock
• The ability to handle the impact of stress.
• Endurance of healthy menstrual flow & menopause
• Balanced hormones

Women are far more sensitive to the rhythms and cycles of nature and Ayurveda is founded on the principle of keeping the body toned in tune with nature.

Herbs such as Shatavar (Asparagus racemosus), Kumari (Aloe vera), Ashwagandha (Withania somnifera), Giloy (Tinospora cordifolia), Revand chini (Rheum emodii), Kalaunji (Nigella sativa), Putrajeevak (Putranjiva roxburghii) etc. are a bliss for Women’s health according to Ayurveda.

• Shatavar (Asparagus racemosus), Kumari (Aloe vera) provides phytoestrogenic action due to presence of saponins, Furostanol saponins which helps in regulation of gynecological clock of the body.
• Ashwagandha (Withania somnifera), Putrajeevak (Putranjiva roxburghii) reduces the levels serotonin & corticosterone to make the body adaptogenic to handle the impact of stress.
• Revand chini (Rheum emodii) is rich source of stilbenes derivatives such as rhaponticin, deoxyrhaponticin which endures healthy menstrual flow.
• Ashwagandha (Withania somnifera) & Giloe (Tinospora cordifolia) are known to regulate HPO axis by encouraging balanced production of female hormones oestrogen & progesterone.

All these & many more potent herbs possess excellent attribute to make AMYCORDIAL which is manufactured by AIMIL PHARMACEUTICALS as complete uterine tonic. Amycordial is known to regularize female system in nature’s way by providing proper therapeutic concentration and nutritional supplementation for restoring feminine health. Thus, Amycordial not only ensures safety and efficacy but also assures health in females through cleansing, nourishing and strengthening whole body.

Ayurveda has a way, when synthetic has limitation – Viral Hepatitis

Liver is an extremely robust organ, performs various vital functions noiselessly, even if larger portions are destroyed.

Viral hepatitis is a cause for major health care burden in India and is now equated as a threat comparable to the “big three” communicable diseases – HIV/AIDS, malaria and tuberculosis.

Hepatitis A virus and Hepatitis E virus are predominantly enterically transmitted pathogens and are responsible to cause both sporadic infections and epidemics of acute viral hepatitis.

 Hepatitis B virus and Hepatitis C virus are predominantly spread via parenteral route and are notorious to cause chronic hepatitis which can lead to grave complications including cirrhosis of liver and hepatocellular carcinoma. 

Who is responsible?

The destructive agent in viral hepatitis is not the virus, but rather the immune system itself. As long as virus lies in dormant in the liver cells, it is undetectable to immune system. When virus begins to multiply, immune response destroys liver tissues and causes most serious symptoms of hepatitis.

Ayurvedic medicine definitely has a lot to offer to the society by way of improving liver health.

Ayurveda has been using various potent herbs to treat several liver ailments, but its efficiency is poorly documented by means of scientific studies. In Ayurveda high number of liver tonics has been prescribed for chronic liver diseases and G.I. disorders. Thirteen classical Ayurveda formulations and eight medicinal plants mostly used by Ayurveda were reviewed along with scientific studies. Arogyavardhini vati is highest prescribed medicine in liver disorders. Haridra, Kutaki, chirayata, punernava, kalmegh, Bhuiamla are commonest single herb used by the herbalist and Ayurvedic physician in the treatment of liver disorders. Many grey areas of hepato billiary disorders can be addressed through scientific research in Ayurveda.

Amlycure D.S was introduced in 1984 and since then, it has been used nationwide as effective liver formula, with beneficial effects from panacea of liver correcting and protecting herbs. Amlycure D.S is safe and effecting in protecting the liver against probable harmful toxins like infective agents, common prescription drugs, alcohol etc.

Amlycure D.S is available in the form of Capsule and Syrup for better patient compliance.

Amlycure D.S is clinically studied at Banaras Hindu University in Acute Viral Hepatitis – shows progressive improvement in biochemical values and symptoms. (By Dr. R. H Singh, B.H.U)

Amlycure D.S benefits with synergism of 32 ingredients in syrup and 29 ingredients in capsules providing drug concentration of 5485 mg/ 10 ml in syrup and 4840 mg/ capsule which makes Amlycure D.S more efficacious & medicine of choice since decades.

Here, some highlights of Amlycure D.S which have potential to improve liver health.

1. Phyllanthus amarus (Bhuiamla) Inhibits reaction between HBsAg & Anti-HBs.

(J of ehnopharmacol.  82, 19-22, 2000)

2. Glycyrrhiza glabra (Yashtimadhu) Locks hepatitis B virus in to the cells and keeps it away from spreading.

(Biomed. Res. Int. 1-15, 2014)

3. Tinospora cordifolia (Giloe) Improves Kupffer Cell activity, tones innate immunity and acts as anti-inflammatory, inhibiting autacoid’s activity, thus boosts body defence system.

(J. Post grad. Med. 40:65, 1994)

4. Andographis paniculata (kalmegh) & Picrrorhiza kurroa (Kutaki) Promotes quicker elimination of toxicants.

(Ind. J. Trad. Knowledge. 10(4), 2011)

5. Plumbago zeylanica (Chitrak) Increases effectiveness of liver functions.

(Int. J. Pharm & Pharmaceut. Sci., 3(1), 151-154, 2011)

6. Ocimum sanctum (Tulsi) Quenches free radicals excessively generated in disease states and prevents lipid per-oxidation.

(Pharmcog. Res. 3(1), 13-18, 2011)

Recommendations

1. Avoid fatty foods entirely, and limit animal protein.

2. Do not take any drugs that have not been prescribed by doctor.

3. Diet restrictions, life style modifications and de-addiction are also the essential factors practiced for the best possible results.

4. Take liver care supplement under supervision of Physician.

AIMIL Signs MOU with Jiwaji University, Gwalior for Advance Research in Ayurveda

In a first, an ayurveda research institute has entered into an industry tie-up to develop new medicine formula using advance sciences like nano-technology, validations & resourcing natural drugs and market new remedies for hitherto incurable diseases at a two days Symposia organized on 18 & 19 January, 2019 at Jiwaji University campus, Gwalior, Madhya Pradesh.

Taking a cue from successful industry tie-ups of the Council of Scientific and Industrial Research (CSIR) and Defence Research and Development Organisation (DRDO), Madhya Pradesh government-funded Jiwaji University has signed an agreement with Delhi-based AIMIL Pharmaceuticals to study centuries-old ayurvedic formulations, standardise and authenticate them and use information about their potent ingredients for developing new medicines.

On the event, Mr. Sanchit Sharma, Executive Director of AIMIL Pharmaceuticals declares that we will pump in resources, like equipment and technology inputs, to help the university utilise its pool of qualified researchers to its optimal potential.

University vice-chancellor Prof. (Dr.) Sangita Shukla thanked the Union Ayush ministry for promoting research in Ayurveda and said, “It is a win-win situation for both the Industry & Institutions, and all throughout globe such provisions of Industry Institutions Interface Projects (IIIP) have significant recognitions for IPR as well as funding from eminent funding institutions. The arrangement will open new avenues for our faculty and students while giving AIMIL access to latest research feedback.” 

Former Secretary of Health, Govt. of India & Former Director General of Indian Council of Medical Research (ICMR) Dr. V.M. Katoch, who was present at the event to sign the agreement, lauded the improved co-ordination between Ayurvedic research institutes and industry. Dr. Katoch in his speech to audience said that “Ayurveda is the key to treating some of the incurable diseases. If old formulations are subjected to modern research in integrated scientific pattern, we will surely be able to develop world-class medicines with negligible but known side effects.”

Highlighting the gains from tie-ups between researchers and industry, he further cited the example of DRDO developed formulation Lukoskin to treat white skin spots or vitiligo and CSIR-developed diabetes formulation called BGR-34. The Union government has tied-up with AIMIL for marketing the two drugs which have even made a foray into all throughout markets.

Dr. Anil Sharma, Vice President, AIMIL Pharmaceuticals India Ltd. has also been invited as Special Guest for invited talk, who gave a presentation on “Ayurveda – An Ancient & Innovative Sciences Opening Vistas in Researches in Modern Aspects” with the objectives to look into advance research to regain healthy India.

In addition, several eminent academicians like Dr Laxman Singh from BHU, Dr P Hemant Kumar from National Institute of Ayurveda, Jaipur, Dr Santosh Bhattad from All India Institute of Ayurveda, Delhi, Renowned Ayurvedist Dr M R Uniyal and academicians from A&U Tibbia College, Delhi, Ch. Brahm Prakash Charak Sansthan, Delhi, Dr Mahesh Sharma, Principal, Government Ayurvedic Medical College, Gwalior, Prof R S Tomar & Prof Nagappa from Amity University, Gwalior and many more have given their benign presentation at the event. The event was organized under the convenorship of Prof. K K Sijoria former Principal, A & U Tibbia College & presently advisor to JiwaJi University and Professor G B K Prasad, HOD Biotechnology department, Jiwaji University and was attended by about 300 delegates comprising faculty, interns & students of Ayurveda colleges & practicing professionals. The University was ranked Grade A by NAAC and also recognize as “Centre of Translational Research” and also progressing to the “Centre of Excellence” from government recognized agencies. The impact of event was further boosted on day two during the clinical workshop.

With an aim to benefit the patients suffering from non-communicable diseases like diabetes, the Indian Government has launched a pilot project integrating allopathic and traditional medicines in its hospitals, setting aside doubts raised by allopathic doctors over efficacy of the alternative drugs and similar activities are going on in university by establishing basic health academic research department, Panchakarma Unit and Diabetes Camps in various rural areas of the state.

The ministry has also roped in scientific institutes such as IIT-Bombay and All India Institute of Medical Sciences for conducting research to counter allegations that Ayurvedic medicines are not effective.

A natural approach to manage diabetes associated wounds

Diabetes mellitus, which is a morbid condition associated with various connective tissue (mainly collagen tissue) abnormalities, is generally associated with delayed wound healing. Delayed wound healing is producing high economic burden on the society. Diabetic foot ulcer is severe most case of delayed wound healing which afflicts 15% of diabetic patients and among these 84% undergo lower-leg amputations. Delay in wound healing, specifically to diabetic patients, is due to ill function/metabolic behavior/chemotaxis of leucocytes resulting in non availability of neutrophils and macrophages to the wound. Basic principle of wound healing is to reduce tissue damage by providing adequate blood supply, oxygenation, proper nutrition and moist environment for healing of the wound It involves the organized and coordinated interaction between extracellular matrix, different types of cells (leukocytes, fibroblasts etc.) and various growth factors such as platelet derived growth factor, epidermal growth factor, fibroblast growth factor etc. Herbal treatment has been targeted in the study, as of their greater demand in market now-a-days.

Amree Plus, a poly-herbal formulation already available in the market, is effective in controlling blood glucose by delaying glucose absorption and other complications related to diabetes. Apart from anti-diabetic action, it also provides toning effect, nutrient supplementation, anti-oxidant, immuno-modulator, anti-ageing, cardio-protection and renal protection. Amree plus exert its effect by activating islets of pancreas and mimicking insulin effect. Phytochemical examination of Amree Plus revealed the presence of flavonoids, tri-terpenoids, saponins, tannins, steroids, proteins, amino acids etc. It consists of many plants reported to have wound healing activity such as Gymnema sylvestre (Gudmar), Pterocarpus marsupium (Vijaysaar), Eclipta alba (Bhringraj), Azadirachta indica (Neem patr), Coccinia indica (Kundru), Nigella sativa (Kalonji), Tinospora cordifolia (Giloe), Aegle marmelos (Bilv patr) etc.

The secondary metabolites of these plants promotes wound healing through different components such as saponins (anti-oxidant and anti-microbial activity), tannins and flavonoids (astringent, anti-microbial property and free radical scavengers), sterols & poly phenols (free radical scavengers, anti-oxidant and reduce lipid peroxidation), tri-terpenoids (promotes wound contraction and rate of epithelialization). This formulation shows good antidiabetic activity and has herbal constituents active as wound healer thus it may heal wound or lessen the duration of delayed wound healing in diabetics.

The effect of polyherbal formulation Amree plus on wound healing has been studied in diabetic and normal animals and compared with standard (Chymoral Forte) using excision wound model. Diabetes was induced by administration of single dose of Streptozotocin 55 mg/kg i.p. The biochemical parameters i.e. hydroxyl proline content, total protein content, glutathione and superoxide dismutase (SOD) were also estimated. Exp animals were treated with Amree Plus at both doses i.e. 1200 and 5400 mg/kg dose per day had significantly high wound contraction both in diabetic and normal rats (88.91 & 95.05 %, respectively) in comparison to respective control. Hydroxyproline content of the granulation tissue and anti-oxidants (glutathione and SOD) level were also showing same pattern in Amree Plus 5400 mg/kg treatment group with respect to controls.

Wound contraction and other biochemical indicators results with animals Amree Plus (1200 mg/kg) treated were found to be statistically equivalent to standard Chymoral forte dose (36 kAU/kg) while Amree Plus 5400 mg/kg dose showed statistically higher results than standard. Amree Plus, an established antidiabetic formulation, was also showing healing of the wound in normal animals along with diabetic animals. So this finding should be confirmed further for more precision with large number of animals and small progression of doses.

Reference : The Journal of Phytopharmacology 2017;6(1):1-10